P7679

Sigma

 

Monoclonal Anti-Platelet-Derived Growth Factor Receptor β antibody produced in mouse

clone PDGFR-B2, ascites fluid

Synonym:Anti-PDGF Rβ
MDL number:MFCD00164777

Description

ImmunogenPDGF β-receptor from pig uterus.
SpecificityThe antibody recognizes human and pig PDGF Rβ, but not mouse or rat. It can be used for immunoperoxidase and immunofluorescence staining of unfixed or acetone-fixed frozen tissue. The antibody induces clustering and down-regulation of PDGF Rβ. The antibody does not cross react with PDGF Rα.

Properties

antibody formascites fluid
clonePDGFR-B2 (monoclonal)
contains15 mM sodium azide
species reactivityhuman, pig
application(s)immunoblotting: 1:100 using denatured, non-reduced porcine uterus extract
 immunohistochemistry (frozen sections): suitable
 immunoprecipitation: suitable
 microarray: suitable
isotypeIgG2b
Gene Informationhuman ... PDGFRB(5159)
shipped indry ice
storage temp.−20°C

Safety

WGK Germany3

Related Products

ArrayXP725, Panorama® Antibody Microarray - XPRESS Profiler725 Kit

References

referenceSorkin, A., et al., Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor. J. Cell Biol. 112, 469-478, (1991) Abstract
 Reuterdahl, C., et al., Characterization of platelet-derived growth factor beta-receptor expressing cells in the vasculature of human rheumatoid synovium. Lab. Invest. 64, 321-329, (1991) Abstract
 Costantino, S., et al., Measurement of monomer-oligomer distributions via fluorescence moment image analysis. Biophys. J. 91, 3884-3896, (2006) Abstract
 Comeau, J., et al., A guide to accurate fluorescence microscopy colocalization measurements. Biophys. J. 91, 4611-4622, (2006) Abstract
 Hoddelius, P., et al., Both intra- and extracellular Ca2+ participate in the regulation of the lateral diffusion of the PDGF-β2 receptor. Biosci. Rep. 20, 119-127, (2000) Abstract